Radiotherapy induces responsiveness of a resistant mammary carcinoma to PD-1 blockade
نویسندگان
چکیده
Background We’ve previously shown that radiotherapy (RT) converts poorly immunogenic tumors resistant to antibodies (mAbs) against the immune checkpoint receptor CTLA-4 into susceptible ones (Demaria et al., 2005; Dewan et al., 2009). Programmed death-1 (PD-1) is another immune checkpoint receptor upregulated on T-cells shortly after activation and expressed at high levels on exhausted Tcells. Anti-PD-1 mAbs have shown marked clinical activity in some cancer patients, but the majority does not respond. Here we tested the hypothesis that RT can sensitize poorly immunogenic tumors to anti-PD-1.
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